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Large-scale genomic study reveals robust activation of the immune system following advanced Inner Engineering meditation retreat
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- 자료유형학술지논문
- 저자명Chandran, Vijayendran, Mei-Ling Bermúdez, Mert Koka, Brindha Chandran, Dhanashri Pawale, Ramana Vishnubhotla, Suresh Alankar, Raj Maturi, Balachundhar Subramaniam, and Senthilkumar Sadhasivam
- 학회/출판사/기관명Springer India
- 출판년도2021
- 언어영어
- 학술지명/학위논문주기Proceedings of the National Academy of Sciences
- 발행사항118, no. 51 (2021).
- ISBN/ISSN03698211, 22501746
- 소개/요약Several studies on the impact of yoga and meditation on mental and physical health have demonstrated beneficial effects. However, the potential molecular mechanisms and critical genes involved in this beneficial outcome have yet to be comprehensively elucidated. This study identified and characterized the transcriptional program associated with advanced meditation practice, and we bioinformatically integrated various networks to identify meditation-specific core network. This core network links several immune signaling pathways, and we showed that this core transcriptional profile is dysfunctional in multiple sclerosis and severe COVID-19 infection. Very importantly, we demonstrated that the meditative practice enhanced immune function without activating inflammatory signals. Together, these results make meditation an effective behavioral intervention for treating various conditions associated with a weakened immune system.
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