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Protocol for a Mechanistic Study of Mindfulness Based Cognitive Therapy During Pregnancy
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- 자료유형학술지논문
- 저자명Seghete, Kristen L. Mackiewicz,Graham, Alice M.,Lapidus, Jodi A.,Jackson, Evelyn L. A.,Doyle, Olivia J.,Feryn, Alicia B.,Moore, Lucille A.,Goodman, Sherryl H.,Dimidjian, Sona
- 학회/출판사/기관명APA AMERICAN PSYCHOLOGICAL ASSOCIATION
- 출판년도2020
- 언어영어
- 학술지명/학위논문주기Health psychology
- 발행사항Vol.39No.9[2020]_x000D_
- ISBN/ISSN0278-6133
- 소개/요약Objective: Preventive interventions for postpartum depression (PPD) are critical for women at elevated risk of PPD. Mindfulness based cognitive therapy - perinatal depression (MBCT-PD) is a preventive intervention that has been shown to reduce risk for PPD in women with a prior history of depression. The objective of this clinical trial is to examine two potential mechanisms of action of MBCT-PD, emotion regulation and cognitive control, using behavioral and neuroimaging methods. Method: This baseline protocol describes a randomized control trial (RCT) with two arms, MBCT-PD and treatment as usual (TAU). We plan on enrolling 74 females with a prior history of a major depressive episode, with 37 participants randomized to each arm. Participants in the MBCT-PD arm will receive MBCT-PD during pregnancy, and the TAU group will receive standard prenatal care. All participants will complete the Center for Epidemiological Studies Depression Scale - Revised (CESD-R), Emotion Regulation Questionnaire (ERQ), and classic Stroop task at multiple points from pregnancy through six months postpartum. Participants will also complete an fMRI scan at six weeks postpartum. Results: All primary outcomes are collected at six weeks postpartum. Primary behavioral outcomes include: depressive symptoms on the CESD-R, cognitive reappraisal on the ERQ, and Stroop task performance. In parallel, the primary neurobiological outcomes include whole-brain activation during fMRI tasks when participants 1) regulate emotional responding and 2) engage cognitive control. Conclusions: This results of this innovative RCT will help identify potential behavioral and neurobiological mechanisms of action of preventive interventions for PPD for in-depth examination in larger scale RCTs. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
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