명상도서관
Adding mindfulness-based cognitive therapy to maintenance antidepressant medication for prevention of relapse/recurrence in major depressive disorder: Randomised controlled trial
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- 자료유형학술지논문
- 저자명Huijbers, M. J.,Spinhoven, P.,Spijker, J.,Ruhé, H. G.,van Schaik, D. J.,van Oppen, P.,Nolen, W. A.,Ormel, J.,Kuyken, W.,van der Wilt, G. J.
- 학회/출판사/기관명Elsevier Science B.V., Amsterdam.
- 출판년도2015
- 언어영어
- 학술지명/학위논문주기JOURNAL OF AFFECTIVE DISORDERS
- 발행사항Vol.187No.-[2015]_x000D_
- ISBN/ISSN0165-0327
- 소개/요약Background Mindfulness-based cognitive therapy (MBCT) and maintenance antidepressant medication (mADM) both reduce the risk of relapse in recurrent depression, but their combination has not been studied. Our aim was to investigate whether the addition of MBCT to mADM is a more effective prevention strategy than mADM alone. Methods This study is one of two multicenter randomised trials comparing the combination of MBCT and mADM to either intervention on its own. In the current trial, recurrently depressed patients in remission who had been using mADM for 6 months or longer (n=68), were randomly allocated to either MBCT+mADM (n=33) or mADM alone (n=35). Primary outcome was depressive relapse/recurrence within 15 months. Key secondary outcomes were time to relapse/recurrence and depression severity. Analyses were based on intention-to-treat. Results There were no significant differences between the groups on any of the outcome measures. Limitations The current study included patients who had recovered from depression with mADM and who preferred the certainty of continuing medication to the possibility of participating in MBCT. Lower expectations of mindfulness in the current trial, compared with the parallel trial, may have caused selection bias. In addition, recruitment was hampered by the increasing availability of MBCT in the Netherlands, and even about a quarter of participants included in the trial who were allocated to the control group chose to get MBCT elsewhere. Conclusions For this selection of recurrently depressed patients in remission and using mADM for 6 months or longer, MBCT did not further reduce their risk for relapse/recurrence or their (residual) depressive symptoms.
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