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T78. Attenuated Default Mode Network Functional Connectivity is Associated With Improvement in Depressive Symptoms Following Mindfulness-Based Cognitive Therapy in a Transdiagnostic Anhedonic Sample
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- 자료유형학술지논문
- 저자명Cernasov, Paul,Greene, Rachel,Kinard, Jessica,Halverson, Tate,Lowery, Sarah,McLamb, Marcy,Choi, David,Cruz, Maria,Armel, Kristen,Luke, Shauntell,Arnold, Macey,Pisoni, Angela,Kelley, Lisalynn,Nagy, Gabriela,Walsh, Erin,Smoski, Moria,Dichter, Gabriel
- 학회/출판사/기관명Elsevier Science B.V., Amsterdam.
- 출판년도2019
- 언어영어
- 학술지명/학위논문주기Biological psychiatry
- 발행사항Vol.85No.S[2019]_x000D_
- ISBN/ISSN0006-3223
- 소개/요약Background Mindfulness-Based Cognitive Therapy (MBCT) is an effective intervention for improving depressive symptoms, but the neural mechanisms associated with treatment response are unclear. Mindfulness strategies promoted in MBCT involve psychological processes supported by the Default Mode Network (DMN) such as present-moment awareness and non-judgmental acceptance. Furthermore, DMN hyperconnectivity has been associated with both global depressive symptoms and with anhedonia specifically. Functional magnetic resonance imaging (fMRI) has not yet been reported to assess changes in DMN connectivity following MBCT in a clinically significant mood-impaired sample. Methods Eleven adults to date, (age; mean= 35.2 SD= 9.45; range=22 – 49 years old; 10 female), with clinically significant anhedonia completed up to 15 weeks of individualized MBCT. 7 Tesla fMRI and Beck’s Depression Inventory-II (BDI) scores were collected pre- and post-treatment. A medial prefrontal cortex (mPFC) seed was used to assess changes in resting-state functional connectivity (RSFC) associated with changes in BDI scores using the CONN toolbox. Results were corrected for multiple comparisons using a false-discovery rate (FDR) adjustment. Results BDI scores significantly decreased following MBCT (Pre-treatment M (SD) =20.3 (10.9), Post-treatment M (SD) =6.2 (7.6); p=0.001). Reductions in BDI scores were positively associated with decreases in RSFC between the mPFC and a cluster in the precuneus, after controlling for age and pre-treatment BDI (adjusted Rˆ2 = 0.91; p-FDR corrected = 0.0342). Conclusions Attenuated RSFC between regions of the anterior and posterior DMN may partially account for the anti-depressant effects of MBCT. DMN connectivity may provide a mechanistic probe for mindfulness-based clinical interventions.
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