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Mindfulness in Parkinson's Disease leads to increases in gray matter density
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- 자료유형학술지논문
- 저자명Pickut, B. A.,Van Hecke, W.,Parizel, P. M.,Cras, P.
- 학회/출판사/기관명Elsevier Science B.V., Amsterdam.
- 출판년도2013
- 언어영어
- 학술지명/학위논문주기Journal of the neurological sciences
- 발행사항Vol.333//SUP1No.-[2013]_x000D_
- ISBN/ISSN0022-510X
- 소개/요약OBJECTIVE: The goal of this study was to evaluate structural brain parenchymatous changes induced by a mindfulness based intervention (MBI) in Parkinson's disease. BACKGROUND: Parkinson's disease (PD) is a complex chronic, progressive neurodegenerative syndrome consisting of motor and non-motor symptoms. Up to half of individuals with PD have mild cognitive impairments in the absence of dementia. In a pilot study, we observed that PD patients could benefit from a Mindfulness based intervention (MBI), interpreted on the basis of self-reported measures. DESIGN/METHODS: A total of 31 PD patients were recruited into a randomized controlled trial comparing MBI consisting of a structured 8-week program of mindfulness training (n = 14) with usual care (UC) (n = 13). 3D T1 weighted (1x1x1 mm3 resolution, Siemens 3T system) MRI data sets were obtained in 27 PD patients, at baseline and after 12 weeks follow-up. Voxel based analysis was performed using DARTEL from the SPM8 software. After image registration, the segmented grey matter images of the baseline were subtracted from the follow-up scan. The resulting difference maps of the MBI and UC group were statistically compared, to examine grey matter density differences in time between both groups. Results were reported at p<0.001, uncorrected for multiple comparisons. RESULTS: An increased grey matter density was found in the MBI group compared to the UC group over time in the right caudate, left and right hippocampus and right amygdala. On the other hand, increased grey matter differences were found in the UC compared to the MBI group in the left cerebellum. CONCLUSIONS: Increased grey matter density was found in the MBI group in regions that have been postulated to play an important role in mediating benefits of meditation. To the best of our knowledge this is the first quantitative analysis of a mindfulness based intervention in PD.
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