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Mindfulness Meditation Modulates Pain Through Endogenous Opioids
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- 자료유형학술지논문
- 저자명Sharon, H.,Maron-Katz, A.,Ben Simon, E.,Flusser, Y.,Hendler, T.,Tarrasch, R.,Brill, S.
- 학회/출판사/기관명Elsevier Science B.V., Amsterdam.
- 출판년도2016
- 언어영어
- 학술지명/학위논문주기The American journal of medicine
- 발행사항Vol.129No.7[2016]_x000D_
- ISBN/ISSN0002-9343
- 소개/요약Background: Recent evidence supports the beneficial effects of mindfulness meditation on pain. However, the neural mechanisms underlying this effect remain poorly understood. We used an opioid blocker to examine whether mindfulness meditation induced analgesia involves endogenous opioids. Methods: 15 healthy experienced mindfulness meditation practitioners participated in a double-blind, randomized, placebo-controlled, crossover study. Participants rated the pain and unpleasantness of a cold stimulus before and after a mindfulness meditation session. Participants were then randomized to receive either intravenous Naloxone or saline, after which they meditated again, and rated the same stimulus. Results: A (3) x (2) repeated measurements ANOVA revealed a significant time effect for pain and unpleasantness scores (both p<.001) as well as a significant condition effect for pain and unpleasantness (both p<.04). Post-hoc comparisons revealed that pain and unpleasantness scores were significantly reduced after natural mindfulness meditation and after placebo, but not after Naloxone. Furthermore, there was a positive correlation between the pain scores following Naloxone versus placebo and participants' mindfulness meditation experience. Conclusions: These findings show, for the first time, that meditation involves endogenous opioid pathways, mediating its analgesic effect and growing resilient with increasing practice to external suggestion. This finding could hold promising therapeutic implications, and further elucidate the fine mechanisms involved in human pain modulation.
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