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Mindfulness practice reduces cortisol blunting during chemotherapy: A randomized controlled study of colorectal cancer patients
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- 자료유형학술지논문
- 저자명Black, D. S.,Peng, C.,Sleight, A. G.,Nguyen, N.,Lenz, H. J.,Figueiredo, J. C.
- 학회/출판사/기관명John Wiley & Sons, Ltd
- 출판년도2017
- 언어영어
- 학술지명/학위논문주기Cancer
- 발행사항Vol.123No.16[2017]_x000D_
- ISBN/ISSN0008-543X
- 소개/요약Background The objective of this randomized clinical experiment was to test the influence of a mindfulness meditation practice, when delivered during one session of active chemotherapy administration, on acute salivary cortisol response as a marker of the neuroendocrine system activity in cancer patients. Methods A mindfulness, attention control, or resting exposure was assigned to N=57 English- or Spanish- speaking colorectal cancer patients at one county oncology clinic and one university oncology clinic at the start of chemotherapy. Four saliva samples were collected at the start of chemotherapy and at subsequent 20-minute intervals during the first 60 minutes of chemotherapy. Self-report on biobehavioral assessments post-chemotherapy included distress, fatigue, and mindfulness. Results Area under the curve analysis (AUCI and AUCB) denoted a relative increase in cortisol reactivity in the mindfulness group after adjusting for biological and clinical measures (β=123.21, p=.03), indicating reduced acute cortisol blunting. More than twice as many patients in the mindfulness group as compared to controls displayed a cortisol rise from baseline to 20 minutes (69% vs. 34%, p=.02). AUCi values were uncorrelated with biobehavioral measure scores although mindfulness scores were inversely correlated with fatigue (r=−.46, p<.01) and distress (r=−.54, p<.01) scores. Conclusions Findings suggest that a mindfulness practice during chemotherapy can reduce blunting of neuroendocrine profiles typically observed in cancer patients. Implications include support for the use of mindfulness practice in integrative oncology.
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