명상도서관
Macrophage Migration Inhibitory Factor and microRNA-451a in Response to Mindfulness-based Therapy or Treatment as Usual in Patients with Depression, Anxiety, or Stress and Adjustment Disorders
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- 자료유형학술지논문
- 저자명Wang, X.,Sundquist, K.,Palmér, K.,Hedelius, A.,Memon, A. A.,Sundquist, J.
- 학회/출판사/기관명Oxford University Press
- 출판년도2018
- 언어영어
- 학술지명/학위논문주기INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- 발행사항Vol.21No.6[2018]_x000D_
- ISBN/ISSN1461-1457
- 소개/요약Background: Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that has been associated with various psychiatric disorders. MicroRNA-451a (miR-451a) can directly target MIF and down-regulate its expression in cells. However, the role of MIF and miR-451a in psychiatric patients treated with psychotherapeutic interventions is unknown. In this study, our aim was to investigate levels of MIF and its regulating miR-451a in patients with depression, anxiety or stress- and adjustment disorders who underwent mindfulness-based therapy or treatment as usual (TAU). Methods: A total of 168 patients with psychiatric disorders were included from a randomized controlled trial that compared mindfulness-based therapy with TAU. Plasma levels of MIF and miR-451a were measured at baseline and after the eight-week follow-up using Luminex assay and qPCR. Results: MIF levels decreased significantly in patients post-treatment, whereas miR-451a levels showed a non-significant change. MIF levels were inversely associated with miR-451a expression levels at baseline (β = -0.04, p=0.008). The change in MIF levels (follow-up levels minus baseline levels) was associated with the change in miR-451a (follow-up levels minus baseline levels) (β = -0.06, p<0.0001). The change in either MIF or miR-451a was not associated with improvement in psychiatric symptoms. Conclusion: We demonstrate that the levels of MIF decreased after psychotherapeutic interventions in patients with psychiatric disorders. However, this reduction was not associated with an improvement in psychiatric symptoms in response to the treatment. We also found an association between MIF and its regulating miRNA. However, this association needs to be further examined in future studies.
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