명상도서관
Mindfulness-Meditation-Based Pain Relief Is Not Mediated by Endogenous Opioids
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- 자료유형학술지논문
- 저자명Zeidan, Fadel,Adler-Neal, Adrienne L.,Wells, Rebecca E.,Stagnaro, Emily,May, Lisa M.,Eisenach, James C.,McHaffie, John G.,Coghill, Robert C.
- 학회/출판사/기관명Society for Neuroscience
- 출판년도2016
- 언어영어
- 학술지명/학위논문주기The Journal of neuroscience
- 발행사항Vol.36No.11[2016]_x000D_
- ISBN/ISSN0270-6474
- 소개/요약Opioidergic mechanisms have been repeatedly demonstrated to be involved in cognitive inhibition of pain (Bandura et al., 1987; Tracey et al., 2002; Wager et al., 2007). Pain relief produced by placebo (Levine et al., 1978; Grevert et al., 1983; Amanzio and Benedetti, 1999; Zubieta et al., 2005; Eippert et al., 2009), conditioned pain modulation (King et al., 2013), and attentional control (Sprenger et al., 2012) is reversed by administration of the opioid antagonist naloxone. Furthermore, brain regions associated with facilitating the cognitive modulation of pain, including the anterior cingulate cortex (ACC), orbitofrontal cortex (OFC), and insula, contain high concentrations of opioid receptors (Jones et al., 1991; Adler et al., 1997; Willoch et al., 1999; Casey et al., 2000; Willoch et al., 2004; Wager et al., 2007) and activation of these opioidergic systems (Petrovic et al., 2002; Zubieta et al., 2005; Bingel et al., 2006; Wager et al., 2007; Eippert et al., 2009; Sprenger et al., 2012) produces analgesia (Tracey et al., 2002; Bingel et al., 2006). Several of these brain regions, such as the ACC and prefrontal cortex (PFC), project to the periaqueductal gray (PAG) (Floyd et al., 2000), a structure that can also be directly activated by opioids. The PAG projects to the rostral ventral medulla (Beitz, 1982; Mantyh, 1983a, 1983b) and in turn projects to the spinal dorsal horn and can inhibit nociceptive processing via multiple neurotransmitter systems (Liebeskind et al., 1973).
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