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Modulation of induced frontocentral theta (Fm-θ) event-related (de-)synchronisation dynamics following mindfulness-based cognitive therapy in Major Depressive Disorder
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- 자료유형학술지논문
- 저자명Schoenberg, P. L.,Speckens, A. E.
- 학회/출판사/기관명Springer Science + Business Media
- 출판년도2014
- 언어영어
- 학술지명/학위논문주기COGNITIVE NEURODYNAMICS
- 발행사항Vol.8No.5[2014]_x000D_
- ISBN/ISSN1871-4080
- 소개/요약Depressive severity has been associated with attenuated neocortical frontal midline theta (Fm-θ) power/ evoked activity. Mindfulness-Based Cognitive Therapy (MBCT) has shown to be a successful novel intervention for Major Depressive Disorder (MDD), albeit precise working mechanisms remain elusive. We examined the hypothesis that MBCT would have modulating effects upon evoked Fm-θ power, in addition to investigating possible mediation of induced event-related de/synchroni-sation (ERD/ERS) dynamics. Fifty one patients with a primary diagnosis of MDD (26 exposed to MBCT vs. 25 wait-list/WL controls) undertook a Go/NoGo task con-sisting of positive, negative and neutral words, further stratified into abstract versus trait adjective matrices. Depressive symptom severity and rumination were also examined. A pattern of enhanced induced Fm-h synchro-nisation during the latter 400–800 ms temporal-window pre-to-post MBCT was observed; the contrary in the WL. Modulated ERD/ERS dynamics correlated to amelioration in depressive and rumination symptoms in the MBCT group. We propose the primary action pathway alluded to a neural disengagement mechanism enacting upon tonic neuronal assemblies implicated in emotional and self-related processing. Due to the complexity and presently undiscovered complete unified scientific understanding of neuro-oscillatory-dynamics, and associated clinical inter-plays; we hypothesise that the electro-cortical and con-nected clinical working pathways of MBCT in depression are multi-levelled constituting nonlinear and interdepen-dent mechanisms, represented by mediated EEG synchro-nisation dynamics. Keywords Fm-theta Á Major Depressive Disorder (MDD) Á Mindfulness-Based Cognitive Therapy (MBCT) Á Event-related (de-)synchronisation (ERD/ERS) Á Oscillatory EEG Á Rumination
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